We review an article from an Indian group that reviewed the impact of a combination of supplements not only on sperm quality, but also on outcome off IVF with ICSI.
This article, authored by B. Gosh et al. is relevant in that it measured buth improvement in semen parameters as well as pregnancy outcome with ICSI.
The treatment included a combination of Vitamin B12, Vitamin C, Folic acid, Zn, L-carnitine, Coenzyme Q -10 and Lycopene.
Findings were as follows
I find it very relevant that the pregnancy outcome showed a positive trend ( although not statistically significant) in this very difficult group of patients.
Significant increase in percentage of sperms with positive modified HOS test (54.3 ± 12.7 vs. 58.9 ± 13.3) and marginal increase in percentage of sperms with acrosomal integrity was observed in post treated samples. Percentage of spermatozoa with damaged or fragmented DNA showed a reduction (20.1 ± 5.9 vs. 18.8 ± 5.1). Fertilization rate increased significantly (23.4 ± 7.8 vs. 66.2 ± 8.5) while pregnancy outcome showed a statistically insignificant improvement (20.3% to 29%).
This is the kind of study that we need to see. There is a body of scientific evidence that suggest that natural supplements may enhance sperm quality in azoospermic men and thereby improve pregnancy outcome. We now need the full support of the scientific and the medical community to create some good studies and further confirm these very positive findings.
You can find the article from the Journal "Fertility and Sterility" , here
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